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Carbamazepine taj API








 

 








 

 

HOME >> API >> API List1 >> Carbamazepine >> Interactions

CARBAMAZEPINE  CAS number 298-46-4 85756-57-6s

INTERACTIONS
CARBAMAZEPINE CAS No 298-46-4

Valproic acid and valnoctamide both interact with carbamazepine, as they inhibit microsomal epoxide hydrolase (mEH), the enzyme responsible for the breakdown of carbamazepine-10,11 epoxide into inactive metabolites

By inhibiting mEH, valproic acid and valnoctamide cause a buildup of the active metabolite, prolonging the effects of carbamazepine and delaying its excretion.

Carbamazepine interacts with multiple drugs and caution should be used in combining other medicines with it. Lower levels of carbamazepine are seen when administrated with phenobarbital, phenytoin (Dilantin), or primidone (Mysoline). Carbamazepine, as CYP 450 inducer, may increase clearance of many drugs, decreasing their blood levels.
Drugs that are more rapidly metabolized with carbamazepine include warfarin (Coumadin), phenytoin (Dilantin), theophylline, and valproic acid (Depakote, Depakote ER, Depakene, Depacon)Carbamazepine levels are elevated when taken with erythromycin, cimetidine (Tagamet), propoxyphene (Darvon), and calcium channel blockers.Carbamazepine also increases the metabolism (destruction) of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies

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