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HOME >> API >> API List1 >> Cefuroxime Axetil >> Drug Description

cefuroxime axetil CAS number 55268-75-2


DRUG DESCRIPTION
Cefuroxime Axetil CAS number 55268-75-2

Cefuroxime is an antibiotic resistant to most betalactamases and is active against a wide range of Gram-positive and Gram -negative organisms. The most important use of the drug is in treating meningitis caused by H. influenzae, meningcocci an pneumococcoi. This is so, because it attains high concentrations in C.S.F.

Cefuroxime is a semi-synthetic analog of cephalosphorin. It is a second-generation antibiotic. Cefuroxime is for parenteral use while cefuroxime axetil is of oral administration. Cefuroxime axetil is hydrolyzed to free cefuroxime, whose in vitro antimicrobial activity is similar to that of cefuroxime. Cefuroxime axetil has a broader spectrum of activity than cephalexin (first-generation). Cefuroxime is active against beta lactamase producing strains of H.influenzae and N.gonorrhoeae, which are normally resistant to ampicillin and penicillin, respectively.Cefuroxime is active against a wide range of Gram-positive and Gram-negative bacteria, including Staph. aureus, Strep. pyogenes, Strep. pneumonia, Neisseria spp. In vitro studies have shown cefuroxime to be better active against Gram-positive and Gram-negative organisms than earlier cephalosphorins such as cephradine and cephaloridine. The overall activity of cefuroxime is comparable to cefamandole, another semi-synthetic cephalosphorin. Cefuroxime interferes with the cell wall synthesis in the bacteria. Therapeutic levels are achieved in CSF only in inflamed conditions.

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