>> Side Effects
CAS number 17321-77-6
The most commonly observed adverse events associated with the use of
clomipramine and not seen at an equivalent incidence among placebo-treated
patients were gastrointestinal complaints, including dry mouth,
constipation, nausea, dyspepsia, and anorexia; nervous system complaints,
including somnolence, tremor, dizziness, nervousness and myoclonus;
genitourinary complaints including changed libido, ejaculatory failure,
impotence and micturition disorder; and other miscellaneous complaints,
including fatigue, sweating, increased appetite, weight gain, and visual
The tabulations that follow list adverse reactions that have also been
observed with clomipramine; these are categorized by organ system and listed
in order of decreasing frequency.
Extrapyramidal effects such as ataxia, also headache, delirium, speech
disorders, muscle weakness, muscle hypertonia, tinnitus, paresthesias of the
extremities, convulsions, EEG changes, hyperpyrexia. Peripheral neuropathy
has been reported with other tricyclic antidepressants.
Drowsiness, fatigue, restlessness, confusion accompanied by disorientation
(particularly in geriatric patients and patients suffering from Parkinson's
disease), anxiety states, agitation, sleep disturbances, insomnia,
nightmares, aggravated depression, hypomania or manic episodes, disturbed
concentration, visual hallucinations, impaired memory, aggressiveness,
yawning, depersonalization, activation of latent psychosis, delusions.
Difficulty with accommodation, slurred speech, urinary retention, hot
flushes, mydriasis, glaucoma, paralytic ileus.
Hypotension, particularly orthostatic hypotension with associated vertigo,
sinus tachycardia, palpitations. A quinidine-like effect and other
reversible ECG changes in patients with normal cardiac status (such as
flattening or inversion of T-waves, depressed S-T segments). Arrhythmias,
hypertension, conduction disorders (e.g. widening of QRS complex, PQ
changes, bundle-branch block), syncope.
Fibrillation, myocardial infarction, stroke and unexpected death in patients
with cardiovascular disorders have been reported with tricyclic
Leukopenia, agranulocytosis, thrombocytopenia, eosinophilia and purpura. One
case of pancytopenia has been reported.
Vomiting, abdominal pain, diarrhea, taste perversion, elevated transaminases,
obstructive jaundice, hepatitis with or without jaundice.
Weight loss, breast enlargement and galactorrhea in the female,
inappropriate antidiuretic hormone (ADH) secretion syndrome, gynecomastia in
the male, changes in blood sugar levels, increase in prolactin levels,
Allergic or Toxic:
Allergic skin reactions (skin rash, urticaria), photosensitization, pruritus,
edema, drug fever.
Abrupt cessation of treatment with tricyclic antidepressants after prolonged
administration may occasionally