Codeine phosphate hemihydrate
Head Injury and Increased Intracranial Pressure: The respiratory depressant
effects of narcotics and their capacity to elevate cerebrospinal-fluid
pressure may be markedly exaggerated in the presence of head injury, other
intracranial lesions, or a preexisting increase in intracranial pressure.
Furthermore, narcotics produce adverse reactions that may obscure the
clinical course in patients with head injuries.
Special Risk Patients: Codeine should be given with caution to certain
patients, s.c. as the elderly or debilitated and those with severe
impairment of hepatic or renal function, hypothyroidism, Addison's disease,
and prostatic hypertrophy or urethral stricture.
Information for the Patient
Codeine may impair the mental and/or physical abilities required for the
performance of potentially hazardous tasks, s.c. as driving a car or
operating machinery. Codeine in combination with other narcotic analgesics,
phenothiazines, sedative hypnotics, and alcohol has additive depressant
Codeine appears in the milk of nursing mothers. Caution should be exercised
when it is administered to a nursing woman.