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Divalproex Sodium Taj Pharmaceuticals Ltd.

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CAS NO.: 76584-70-8


 


 










 

 

HOME >> API >> API List1 >> Divalproex Sodium >> Drug Description

Divalproex Sodium CAS NO.: 76584-70-8


DRUG DESCRIPTION
Divalproex Sodium CAS NO.: 76584-70-8

Divalproex sodium is an anticonvulsant (antiseizure) drug. It is also used to treat mania and to help prevent migraine headaches. It is sold under multiple brand names in the United States, including Depacon, Depakene, Depakote, and Depakote sprinkle.Divalproex sodium is effective in the treatment of epilepsy, particularly for preventing simple, complex (petit mal), absence, mixed, and tonic-clonic (grand mal) seizures. Divalproex sodium is also used to treat the manic phase of bipolar disorder (also called manic-depressive disorder) in adults, and to prevent migraine headache in adults.

Divalproex sodium is chemically compounded from sodium valproate and valproic acid in a 1:1 ratio.

Divalproex sodium is thought to work by increasing the levels of a brain neurotransmitter called gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter, which means that its presence makes it harder for nerve cells (neurons) in the brain to become activated (fire). It is believed that increasing GABA's inhibitory action on brain neurons accounts for the ability of divalproex sodium to decrease seizures, curb manic behaviors, and decrease the frequency of migraine headaches.

Divalproex sodium was discovered to decrease the likelihood of seizure in 1963. In 1978, the United States Food and Drug Administration approved it for this use. Other uses for divalproex sodium were researched and approved subsequently, including use against mania (1995) and use to decrease migraine headache frequency.

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