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Magnesium Valproate

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Magnesium Valproate CAS Registry Number 63372-86-1











 










 

 

 

HOME >> API >> API List 2 >> Magnesium Valproate >> Dosage

Magnesium Valproate

DOSAGE
Magnesium Valproate CAS Registry Number 62959-43-7

Magnesium Valproate is indicated as adjunctive therapy for partial seizures, the generalized seizures of Lennox-Gastaut syndrome, and primary generalized tonic-clonic seizures in adult and pediatric patients

Magnesium Valproate is indicated for conversion to monotherapy in adults with partial seizures who are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single AED.

General Dosing Considerations for Epilepsy and Bipolar Disorder Patients

The risk of nonserious rash is increased when the recommended initial dose and/or the rate of dose escalation of Magnesium Valproate is exceeded. There are suggestions, yet to be proven, that the risk of severe, potentially life-threatening rash may be increased by  coadministration of Magnesium Valproate with valproate, exceeding the recommended initial dose of Magnesium Valproate, or  exceeding the recommended dose escalation for Magnesium Valproate. However, cases have been reported in the absence of these factors  Therefore, it is important that the dosing recommendations be followed closely.

It is recommended that Magnesium Valproate not be restarted in patients who discontinued due to rash associated with prior treatment with Magnesium Valproate, unless the potential benefits clearly outweigh the risks. If the decision is made to restart a patient who has discontinued Magnesium Valproate, the need to restart with the initial dosing recommendations should be assessed. The greater the interval of time since the previous dose, the greater consideration should be given to restarting with the initial dosing recommendations. If a patient has discontinued Magnesium Valproate for a period of more than 5 half-lives, it is recommended that initial dosing recommendations and guidelines be followed.

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