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HOME >> API >> API List 2 >> Metformin Hcl >> Interaction

INTERACTION
Molecular Structure CAS number 1115-70-4]

The H2-receptor antagonist cimetidine causes an increase in the plasma concentration of metformin, by reducing clearance of metformin by the kidneysboth metformin and cimetidine are cleared from the body by tubular secretion, and both, particularly the cationic (positively charged) form of cimetidine, may compete for the same transport mechanism.A small double-blind, randomized study found the antibiotic cefalexin to also increase metformin concentrations by a similar mechanismtheoretically, other cationic medications may produce the same effect

You may be more likely to have hyperglycemia (high blood sugar) if you are taking metformin with other drugs that raise blood sugar.
Drugs that can raise blood sugar include

*isoniazid;
*diuretics (water pills);
*steroids (prednisone and others);
*phenothiazines (Compazine and others);
*thyroid medicine (Synthroid and others);
*birth control pills and other hormones;
*seizure medicines (Dilantin and others); and
*diet pills, or medicines to treat asthma, colds or allergies.

You may be more likely to have hypoglycemia (low blood sugar) if you are taking metformin with other drugs that lower blood sugar.
Drugs that can lower blood sugar include

*some nonsteroidal anti-inflammatory drugs (NSAIDs);
*aspirin or other salicylates (including Pepto-Bismol);
*sulfa drugs (Bactrim and others);
*a monoamine oxidase inhibitor (MAOI);
*beta-blockers (Tenormin and others); or
*probenecid (Benemid).

Some medications may interact with metformin.

*furosemide (Lasix);
*nifedipine (Adalat, Procardia);
*cimetidine (Tagamet) or ranitidine (Zantac);
*amiloride (Midamor) or triamterene (Dyrenium);
*digoxin (Lanoxin);
*morphine (MS Contin, Kadian, Oramorph);
*procainamide (Procan, Pronestyl, Procanbid);
*quinidine (Cardioquin, Quinidex, Quinaglute);
*trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra); or
*vancomycin (Vancocin, Lyphocin).

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