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HOME >> API >> API List 3 >> Oxaliplatin >> Side Effects

SIDE EFFECTS
Oxaliplatin CAS Registry Number 61825-94-3

Each person’s reaction to chemotherapy is different. Some people have very few side effects, while others experience more. The side effects described in this information will not affect everyone who is given oxaliplatin and may be different if you are having more than one chemotherapy drug.

We have outlined the most common side effects as well as rarer ones, so that you can be aware of them if they occur. However, we have not included those that are very rare and therefore extremely unlikely to affect you. If you notice any effects which you think may be due to the drug, but which are not listed in this information, please discuss them with your doctor or chemotherapy nurse.

Numbness or tingling in hands or feet Oxaliplatin can have an effect on the nerve endings, which is known as peripheral neuropathy. This may result in feelings of numbness or tingling, especially in the hands, feet, neck or throat.

For some people, these symptoms can be triggered by anything cold, such as iced drinks and cold air. If you notice that your symptoms are related to the cold you should avoid cold drinks and wrap up warmly in the cold weather. It is important to report your symptoms to your doctor as they may be controlled by slightly lowering the dose of the drug.

Sometimes the tingling or numbness may not happen with the first treatment, but after several treatments. This is known as a ‘cumulative effect’ and should improve after the treatment has finished.

Lowered resistance to infection Oxaliplatin can reduce the production of white blood cells by the bone marrow, making you more prone to infection. This effect can begin seven days after treatment has been given. Your blood cells will then increase steadily and will usually have returned to normal before your next cycle of chemotherapy is due.

Contact your doctor or the hospital straightaway if:

* your temperature goes above 38ºC (100.5ºF)
* you suddenly feel unwell (even with a normal temperature).

You will have a blood test before having more chemotherapy to make sure that your cells have recovered. Occasionally it may be necessary to delay your treatment if the number of blood cells (the blood count) is still low.

Bruising or bleeding Oxaliplatin can reduce the production of platelets (which help the blood to clot). Let your doctor know if you have any unexplained bruising or bleeding, such as nosebleeds, blood spots or rashes on the skin, or bleeding gums.

Anaemia (low number of red blood cells) While having treatment with oxaliplatin you may become anaemic. This may make you feel tired and breathless. Let your doctor or nurse know if these symptoms are a problem.

Feeling sick (nausea) and being sick (vomiting) If you do feel sick this may begin a few hours after the treatment is given and last for a few days. Your doctor can prescribe very effective anti-sickness (anti-emetic) drugs to prevent, or greatly reduce, nausea and vomiting. If the sickness is not controlled, or continues, tell your doctor; they can prescribe other anti-sickness drugs which may be more effective. Some anti-sickness drugs can cause constipation. Let your doctor or nurse know if this is a problem.

Diarrhoea This can usually be easily controlled with medicine but tell your doctor if it is severe or if it continues. It is important to drink plenty of fluids if you have diarrhoea.

Tiredness and feeling weak You may feel very tired. It is important to allow yourself plenty of time to rest.

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