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Oxethazaine

HOME >> API >> API List 3 >> Oxethazaine >> Drug Description

DRUG DESCRIPTION
Oxethazaine CAS Registry Number 126-27-2

Oxethazaine is amide anesthetic, witha prolong duration of action. Oxethazaine is designated as N, N-bis-(N-methyl-N-phenyl-butyl-acetamide)-betahydroxyethylamine. Oxethazaine is given by mouth along with antacid for the symptomatic relief of gastro-oesophageal reflux disease. Oxethazaine is also used in the ointments and suppositories for the relief of pain associated with haemorrhoids.

Gastroscopic observations reveal that alumina gel, especially when swallowed undiluted, forms a diffuse coating over the inflamed gastric mucosa for a variable period of time. Because of this adherent vehicle, oxethazaine exerts a prolonged topical anesthetic action.

Oxethazaine is a topical anesthetic which when applied to the mucous membranes produces a more potent anesthesia of longer duration than either cocaine or lidocaine. An ultra-dilute solution of 0.0005% oxethazaine induces the same duration of anesthesia of rabbit cornea as does the more concentrated 0.25% solution of cocaine; as a 1% solution of lidocaine; or as a 2% solution of procaine.

The higher order of potency of oxethazaine permits clinical use of dilute solutions; a 0.2% concentration of oxethazaine in alumina gel is therapeutically effective. In vitro, oxethazaine produces antispasmodic action on smooth muscle. It antagonizes the action of serotonin on smooth muscle as demonstrated on isolated rabbit jejunum strips.

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