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HOME >> API >> API List 3 >> Pamidronate Disodium >> Drug Description

pamidronate Disodium CAS Registry Number 109552-15-0

DRUG DESCRIPTION

Pamidronate Disodium  CAS Number 109552-15-0

Pamidronate disodium is a white-to-practically-white powder. It is soluble in water and in 2N sodium hydroxide, sparingly soluble in 0.1N hydrochloric acid and in 0.1N acetic acid, and practically insoluble in organic solvents.Inactive Ingredients. Mannitol, USP, and phosphoric acid (for adjustment to pH 6.5 prior to lyophilization).

Distribution
Adsorbed to bone in areas of high turnover.
Metabolism

Not metabolized.
Elimination

Treatment of moderate to severe hypercalcemia associated with malignancy with or without bone metastases; treatment of moderate to severe Paget disease of bone; treatment of osteolytic bone lesions of multiple myeloma and bone metastases of breast cancer in conjunction with standard chemotherapy.
Unlabeled Uses

Treatment of postmenopausal osteoporosis; treatment of hyperparathyroidism; prevention of glucocorticoid-induced osteoporosis; management of immobilization-related hypercalcemia; reduction of bone pain in prostatic carcinoma.

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Pamidronate Disodium

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