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HOME >> API >> API List 3 >> Piroxicam Betacyclodextrine >> Interaction

INTERACTION
Piroxicam Betacyclodextrine CAS Number 96684-40-1

Aspirin: When Piroxicam Betacyclodextrine is administered with aspirin, its protein binding is reduced, although the clearance of free Piroxicam Betacyclodextrine is not altered. Plasma levels of piroxicam are depressed to approximately 80% of their normal values when Piroxicam Betacyclodextrine is administered (20 mg/day) in conjunction with aspirin (3900 mg/day). The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of piroxicam and aspirin is not generally recommended because of the potential for increased adverse effects.

Methotrexate: NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
Diuretics: Clinical studies, as well as postmarketing observations, have shown that Piroxicam Betacyclodextrine can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failureWarfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone

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