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Ropinirole Taj Pharmaceuticals Ltd.

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HOME >> API >> API List 3 >> Ropinirole >> Interaction

Ropinirole CAS Registry Number 91374-21-9

INTERACTION

Ropinirole CAS Registry Number 91374-21-9

Tell your doctor of any over-the-counter or prescription medication you may take, including: metoclopramide, medication for psychosis/anxiety/depression, other drugs used for Parkinson's, cimetidine, sleep medication, certain muscle relaxants, tranquilizers, narcotic pain relievers, anti-seizure drugs, certain antihistamines (e.g., diphenhydramine), ciprofloxacin. Do not start or stop any medicine without doctor or pharmacist approval.

L-dopa: Co-administration of carbidopa + L-dopa with ropinirole (2 mg 3 times daily) had no effect on the steady-state pharmacokinetics of ropinirole . Oral administration of Ropinirole  2 mg 3 times daily increased mean steady state Cmax of L-dopa by 20%, but its AUC was unaffected.

Digoxin: Co-administration of Ropinirole  (2 mg 3 times daily) with digoxin (0.125 to 0.25 mg once daily) did not alter the steady-state pharmacokinetics of digoxin in 10 patients.

Theophylline: Administration of theophylline (300 mg twice daily, a substrate of CYP1A2) did not alter the steady-state pharmacokinetics of ropinirole (2 mg 3 times daily) in 12 patients with Parkinson's disease. Ropinirole (2 mg 3 times daily) did not alter the pharmacokinetics of theophylline (5 mg/kg IV) in 12 patients with Parkinson's disease.

Ciprofloxacin: Co-administration of ciprofloxacin (500 mg twice daily), an inhibitor of CYP1A2, with ropinirole (2 mg 3 times daily) increased ropinirole AUC by 84% on average and Cmax by 60%.

Estrogens: Population pharmacokinetic analysis revealed that estrogens (mainly ethinylestradiol: intake 0.6 to 3 mg over 4-month to 23-year period) reduced the oral clearance of ropinirole by 36% in 16 patients. Dosage adjustment may not be needed for Ropinirole  in patients on estrogen therapy because patients must be carefully titrated with ropinirole to tolerance or adequate effect. However, if estrogen therapy is stopped or started during treatment with Ropinirole , then adjustment of the dose of Ropinirole  may be required.

Dopamine Antagonists: Since ropinirole is a dopamine agonist, it is possible that dopamine antagonists such as neuroleptics (phenothiazines, butyrophenones, thioxanthenes) or metoclopramide may diminish the effectiveness of Ropinirole . Patients with major psychotic disorders treated with neuroleptics should only be treated with dopamine agonists if the potential benefits outweigh the risks.

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