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HOME >> API >> API List 3 >> Temozolomide >> Side Effects

SIDE EFFECTS
Temozolomide CAS number 85622-93-1

Each person’s reaction to chemotherapy is different. Some people have very few side effects, while others may experience more. The side effects described in this information will not affect everyone who is given temozolomide, and may be different if you are having more than one chemotherapy drug. Lowered resistance to infection Temozolomide can reduce the production of white blood cells by the bone marrow, making you more prone to infection. This effect can begin seven days after treatment has been given, and your resistance to infection usually reaches its lowest point 10–14 days after chemotherapy. Your blood cells will then increase steadily and will usually have returned to normal levels within 21–28 days

Bruising or bleeding Temozolomide can reduce the production of platelets (which help the blood to clot). Let your doctor know if you have any unexplained bruising or bleeding, such as nosebleeds, blood spots or rashes on the skin, or bleeding gums.

Anaemia (low number of red blood cells) While having treatment with temozolomide you may become anaemic. This may make you feel tired and breathless. Let your doctor or nurse know if these symptoms are a problem.

Feeling sick (nausea) and being sick (vomiting) If you do feel sick this may begin soon after the treatment is given and last for a day. Your doctor can prescribe very effective anti-sickness (anti-emetic) drugs to prevent, or greatly reduce, nausea and vomiting. If the sickness is not controlled, or continues, tell your doctor; they can prescribe other anti-sickness drugs which may be more effective. Some anti-sickness drugs can cause constipation. Let your doctor or nurse know if this is a problem.

Diarrhoea This can usually be easily controlled with medicine, but it is important to let your doctor know if it is severe or continues. It is important to drink plenty of fluids if you have diarrhoea.

Constipation Constipation can usually be relieved by drinking plenty of fluids, eating a high fibre diet and taking gentle exercise. Sometimes you may need to take medicines to stimulate your bowel. These can be prescribed by your doctor.

Loss of appetite and temporary taste alterations Both of these may occur. A dietitian or specialist nurse at your hospital can give advice on boosting appetite, coping with eating difficulties and maintaining weight.

Rashes Temozolomide can cause a rash which may be itchy. Your doctor can prescribe treatment to help reduce this.

Headache Let your doctor know if you have headaches while having treatment with temozolomide.

Tiredness and feeling weak You may feel very tired. It is important to allow yourself plenty of time to rest.

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