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HOME >> API >> API List 3 >> Tizanidine Hcl >> Interaction

Tizanidine Hcl Molecular Formula C9H8ClN5S.HCl

INTERACTION

Tizanidine Hcl CAS Registry Number 64461-82-1


Tell your doctor of all prescription and nonprescription medications you may take, especially of: blood pressure drugs (e.g., water pills, clonidine, methyldopa, guanabenz, guanfacine), MAO inhibitors (e.g., linezolid, furazolidone, phenelzine, selegiline), sleep medicines, sedatives (e.g., diazepam), tranquilizers, anti-anxiety drugs, narcotic pain relievers (e.g., codeine, morphine), barbiturates (e.g., phenobarbital), certain antihistamines (e.g., diphenhydramine), other muscle relaxants (e.g., cyclobenzaprine), certain antidepressants (e.g., imipramine, amitriptyline, trazodone), phenothiazine psychiatric drugs (e.g., chlorpromazine), birth control pills, rofecoxib.

Acetaminophen: Tizanidine delayed the Tmax of acetaminophen by 16 minutes. Acetaminophen did not affect the pharmacokinetics of tizanidine.

Alcohol: Alcohol increased the AUC of tizanidine by approximately 20% while also increasing its Cmax by approximately 15%. This was associated with an increase in side effects of tizanidine. The CNS depressant effects of tizanidine and alcohol are additive.

Fluvoxamine: Clinically significant hypotension (decreases in both systolic and diastolic pressure) has been reported with concomitant administration of fluvoxamine following single doses of 4 mg.

Caution is recommended when considering concomitant use of tizanidine with other inhibitors of CYP1A2, such as, antiarrhythmics (amiodarone, mexiletine, propafenone), cimetidine, fluoroquinolones (ciprofloxacin, norfloxacin), rofecoxib, oral contraceptives, and ticlopidine.

Oral Contraceptives: No specific pharmacokinetic study was conducted to investigate interaction between oral contraceptives and tizanidine, but retrospective analysis of population pharmacokinetic data following single and multiple dose administration of 4 mg tizanidine showed that women concurrently taking oral contraceptives had 50% lower clearance of tizanidine than women not on oral contraceptives.

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Tizanidine Hcl

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