3- ethyl 5-methyl ester
Amlodipine Maleate Description
Amlodipine besylate is the besylate salt of Amlodipine, a
long-acting calcium channel blocker.
Amlodipine besylate is chemically described as
monobenzenesulphonate. Its molecular formula is C20H25CIN2O5•C6H6O3S,
and its structural formula is:
Amlodipine is a dihydropyridine calcium antagonist (calcium
ion antagonist or slow-channel blocker) that inhibits the
transmembrane influx of calcium ions into vascular smooth muscle and
cardiac muscle. Experimental data suggest that Amlodipine binds to
both dihydropyridine and nondihydropyridine binding sites. The
contractile processes of cardiac muscle and vascular smooth muscle
are dependent upon the movement of extracellular calcium ions into
these cells through specific ion channels.
Cosopt lowers high pressure
in the eye, a problem typically caused by the condition known as
open-angle glaucoma. Cosopt works by reducing production of the
liquid that fills the eyeball.
Norvasc does not change
sinoatrial nodal function or atrioventricular conduction in intact
animals or man. In patients with chronic stable angina, intravenous
administration of 10 mg did not significantly alter A-H and H-V
conduction and sinus node recovery time after pacing. Similar
results were obtained in patients receiving Norvasc and concomitant
beta-blockers. In clinical studies in which Norvasc was administered
in combination with beta-blockers to patients with either
hypertension or angina, no adverse effects on electrocardiographic
parameters were observed. In clinical trials with angina patients
alone, Norvasc therapy did not alter electrocardiographic intervals
or produce higher degrees of AV blocks.