Phenyl Propanolamine BP/USP

Item Number  : PH157
CAS Number  : 154-41-6
Molecular Formula : C9H13NO.HCl

Molecular Weight  : 187.67

Synonyms (1RS,2SR)-2-Amino-1-phenylpropan-1-ol Hydrochloride; (+/-)-Norephedrine Hydrochloride 


Phenylpropanolamine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in your body. Constriction of blood vessels in your sinuses, nose, and chest allows drainage of those areas, which decreases congestion.

Phenylpropanolamine is used to treat the congestion associated with allergies, hay fever, sinus irritation, and the common cold. Phenylpropanolamine also causes a decrease in appetite and is used in some over-the-counter diet aids.

Phenylpropanolamine has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Additional Information
DEA scheduled list 1 chemical. Subject to procurement quota requirements
Phenylpropanolamine (PPA; Accutrim, Dexatrim), also knwon as norephedrine and oxyamphetamine, is a psychoactive drug of the phenethylamine and amphetamine chemical classes which is used as a stimulant, decongestant, and anorectic agent.[1][2] It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to control urinary incontinence in dogs under trade names Propalin and Proin.

PPA acts as a potent and selective releasing agent of norepinephrine and epinephrine, or as a norepinephrine releasing agent (NRA). It also acts as a dopamine releasing agent (DRA) to a lesser extent.

INTERACTIONS WITH OTHER DRUGS
In some cases of urinary incontinence, phenylpropanolamine is used in combination with diethylstilbesterol (an estrogen). No harmful drug interactions are expected with this combination.

Phenylpropanolamine should not be used with L-Deprenyl (Anipryl) due to resulting unpredictable fluctuations in blood pressure. 

It is recommended that phenylpropanolamine be withdrawn for 2 weeks preceding the use of L-Deprenyl.

An increased risk of hypertension can also occur if phenylpropanolamine is given in conjunction with tricyclic antidepressants (such as amitriptyline), non-steroidal anti-inflammatory drugs (NSAIDs), or amitraz (active ingredient of the Preventic tick control collar and canine Promeris, a flea control product).

Storage Information

LIGHT SENSITIVE: Keep tightly closed in light-resistant containers.