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cough and mild pain

HOME >> API >> API List 4 >> Ethylmorphine HCl >> Drug Description

DRUG DESCRIPTION
Ethylmorphine HCl Cas No. 25-30-4

Ethylmorphine is a drug in the class of both opiates (representing a minor synthetic change from morphine) and opioids (being effective in the CNS's opioid reception system). Its effects in humans mainly stem from its metabolic conversion to morphine. It was invented in Germany at Merck during the 1880s and was used as weaker alternative to heroin for all indications.

Chemically, ethylmorphine is a morphine molecule with a -OC2H5 group substituted for the aromatic 3-OH group. Therefore the closest chemical relative of ethylmorphine is codeine, also known as methylmorphine. Ethylmorphine also has a hydromorphone analogue (ethyldihydromorphinone or 3-ethoxy-7,8-dihydro-morphin-6-one), and a dihydromorphine analogue known as ethyldihydromorphine, although none of them appears to be commercially distributed at the current time.
As is the case with all narcotic analgesics, ethylmorphine is potentially habit-forming and can generate drug dependence of the codeine type. In most countries and internationally ethylmorphine and codeine are regulated much the same way. Like codeine, dihydrocodeine and similar weak opioid drugs, ethylmorphine is listed in the UN Convention on Narcotic Drugs in a schedule which leads to some ethylmorphone preparations being available over the counter in some countries. In the US, ethylmorphine--like its methyl analogue codeine--is Schedule II as a pure compound and Schedule III when combined with non-opioid analgesics such as paracetamol (akin to Schedule III paracetamol/codeine combinations sold under the brand name Tylenol 3/4). In theory, cough syrup containing ethylmorphine is listed in the United States' Controlled Substances Act under Schedule V, meaning that it can be bought without prescription in certain states if the patient presents ID and/or the chemist knows the person and the patient signs a dispensary log that is monitored by the DEA. However, there are currently no ethylmorphine-based pharmaceuticals marketed in the US, making this a moot point; codeine-based products, on the other hand, are still relatively common.

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