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HOME >> API >> API List 4 >> Phenobarbital Acid

Phenobarbital acid CAS Registry Number 50-06-6

Phenobarbital acid

Molecular Formula C12H12N2O3

Molecular Weight 232.24

CAS Registry Number 50-06-6

Pharmacokinetic data

Bioavailability >95%
Protein binding 20 to 45%
Metabolism Hepatic (mostly CYP2C19)
Half life 53 to 118 hours
Excretion Renal and fecal

Phenobarbital is indicated in the treatment of all types of seizures except absence seizuresPhenobarbital is no less effective at seizure control than more modern drugs such as phenytoin and carbamazepine. It is, however, significantly less well tolerated

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