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Glibornuride api

HOME >> API >> API List 4 >> Glibornuride >> Side Effects

SIDE EFFECTS
Glibornuride CAS No. 26944-48-9

Side-effects

Lactic acidosis

The most serious side effect of Glibornuride is lactic acidosis. However, this complication is rare if the contra-indications are followed, as it seems limited to those with impaired liver and/or kidney function.

Gastrointestinal

The most common side effect of Glibornuride is gastrointestinal upset. This includes diarrhoea, cramps, nausea and vomiting. In a clinical trial of 286 subjects, 53.2% of the 141 who were given Glibornuride IR (as opposed to placebo) reported diarrhoea, and 25.5% reported nausea/vomiting.

The side effect of gastrointestinal upset can be source of severe discomfort for patients. It is very common when Glibornuride is first administered, or when the dose is increased. The discomfort can often be avoided by beginning and increasing the dose gradually. Gastrointestinal upset after prolonged, steady use is less common.

Long-term use of Glibornuride has been associated with malabsorption of vitamin B12. The dose and duration of Glibornuride use predicts B12 deficiency, and some researchers recommend screening or prevention strategies.

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