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anti-malarial medication,

HOME >> API >> API List 4 >> Hydroxychloroquine Sulphate >> Drug Description

DRUG DESCRIPTION
Hydroxychloroquine sulphate CAS No: 747-36-4

Hydroxychloroquine is classified as an anti-malarial medication, and is one of a number of drugs which have been used for many years in the treatment of malaria. It is useful in treating systemic lupus erythematosus as well as rheumatoid arthritis and Sjögren's Syndrome (all rheumatic disorders). While hydroxychloroquine has been known for some time to decrease lysosomal pH in antigen presenting cells, its mechanism of action in inflammatory conditions has been recently elucidated and involves blocking the activation of toll-like receptors on plasmacytoid dendritic cells (PDCs). Toll-like receptor 9 (TLR 9), which recognizes DNA-containing immune complexes leads to the production of interferon and causes the dendritic cells to mature and present antigen to T cells. Hydroxychloroquine, by decreasing TLR signaling reduces the activation of dendritic cells, thus mitigating the inflammatory process.

Hydroxychloroquine is also widely used in the treatment of chronic Lyme disease, in combination with macrolide antibiotics such as clarithromycin. It is thought that the hydroxychloroquine raises the pH in cellular vacuoles in which semi-dormant Lyme spirochaetes live, allowing the effect the macrolide to suppress protein synthesis by the spirochaetes.

Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-[[4-[(7-Chloro-4-quinolyl) amino]pentyl] ethylamino] ethanol sulfate (1:1).

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