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Noroxymorphone

HOME >> API >> API List 4 >> Noroxymorphone >> Drug Descriptin

DRUG DESCRIPTION
Noroxymorphone CAS No.: 33522-95-1

Noroxymorphone is one of the major metabolites of oxycodone. Although oxycodone is commonly used in the treatment of acute and chronic pain, little is known about the antinociceptive effects of noroxymorphone. We present an in vivo pharmacological characterization of noroxymorphone in rats.

METHODS: The antinociceptive properties of noroxymorphone were studied with thermal and mechanical models of nociception in rats.

(diethoxycarbonyl)normorphine, which may be prepared by reaction of morphine with ethyl chloroformate, is converted to (diethoxycarbonyl)normorphinone, a novel compound, by oxidation. The novel normorphinone derivative is converted to (diethoxycarbonyl)normorphinone enol acetate, a second novel compound, by esterification with acetic anhydride or acetyl halide.

A 14-hydroxy group is introduced into the novel dienol ester by oxidation with peracid. The resultant 14-hydroxy-3,17-(diethoxycarbonyl)normorphinone, a third novel compound, may be catalytically hydrogenated to produce 3,17-(diethoxycarbonyl)noroxymorphone. The latter intermediate may be converted to noroxymorphone by hydrolysis.

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