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HOME >> API >> API List 4 >> Oxycodone >> Interaction

INTERACTION
Oxycodone CAS number 76-42-6

Oxycodone, like other narcotic pain-relievers, increases the effect of drugs that slow brain function, such as alcohol, barbiturates, skeletal muscle relaxants, for example, carisoprodol, cyclobenzaprine , and benzodiazepines, for example, lorazepam Combined use of muscle relaxants and oxycodone may lead to increased respiratory depression.

Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate and loperamide , in persons taking oxycodone, can lead to severe constipation.

Drugs which stimulate and also block opioid receptors [or example, pentazocine, nalbuphine , butorphanol , buprenorphine may reduce the effect of oxycodone and may precipitate withdrawal symptoms.

Oxycodone is metabolized in part to oxymorphone via cytochrome P450 2D6. While this pathway may be blocked by a variety of drugs (e.g., certain cardiovascular drugs including amiodarone and quinidine as well as polycyclic antidepressants), such blockade has not yet been shown to be of clinical significance with this agent. Clinicians should be aware of this possible interaction, however.

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