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HOME >> API >> API List 4 >> Oxymorphone >> Drug Description

DRUG DESCRIPTION
Oxymorphone CAS number 76-41-5

Oxymorphone is in a group of drugs called narcotic pain relievers. It is similar to morphine.

Oxymorphone is used to treat moderate to severe pain. The extended-release form of this medication is for around-the-clock treatment of pain.

Oxymorphone is not for treating pain just after surgery unless you were already taking oxymorphone before the surgery.

Oxymorphoneis a powerful semi-synthetic opioid analgesic It is related to morphine in the same fashion that oxycodone is to codeine, is derived from thebaine, and is approximately 6–8 times more potent than morphine. It differs from morphine in its effects all other things being equal in that it generates more euphoria, but less itching and other histamine effects. Depending on the individual patient, it can be either more or less nausea- and vomit-inducing than morphine.

Chemically, oxymorphone is 4, 5α -epoxy-3, 14-dihydroxy-17-methylmorphinan-6-one , a white or slightly off-white, odorless powder, which is sparingly soluble in alcohol and ether, but freely soluble in water. The molecular weight of oxymorphone is 337.80. The pKa1 and pKa2 of oxymorphone at 37°C are 8.17 and 9.54, respectively. The octanol/aqueous partition coefficient at 37°C and pH 7.4 is 0.98.

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