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Rivastigmine tartrate

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HOME >> API >> API List 3 >> Rivastigmine Tartrate >> Drug Description

Rivastigmine Tartrate CAS Registry Number 129101-54-8

DRUG DESCRIPTION
Rivastigmine Tartrate
CAS Registry Number 129101-54-8

Rivastigmine Tartrate (rivastigmine tartrate) is a reversible cholinesterase inhibitor and is known chemically as (S)-N-Ethyl-N-methyl-3-[1-(dimethylamino)ethyl]-phenyl carbamate hydrogen-(2R,3R)-tartrate. Rivastigmine tartrate is commonly referred to in the pharmacological literature as SDZ ENA 713 or ENA 713. It has an empirical formula of C14H22N2O2C4H6O6 (hydrogen tartrate salt - hta salt) and a molecular weight of 400.43 (hta salt). Rivastigmine tartrate is a white to off-white, fine crystalline powder that is very soluble in water, soluble in ethanol and acetonitrile, slightly soluble in n-octanol and very slightly soluble in ethyl acetate. The distribution coefficient at 37C in n- octanol/phosphate buffer solution pH 7 is 3.0.rivastigmine tartrate, equivalent to 1.5, 3, 4.5 and 6 mg of rivastigmine base for oral administration. Inactive ingredients are hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, and silicon dioxide. Each hard-gelatin capsule contains gelatin, titanium dioxide and red and/or yellow iron oxides.

Rivastigmine Tartrate is used in the treatment of mild to moderate Alzheimer's disease. Alzheimer's disease causes physical changes in the brain that disrupt the flow of information and interfere with memory, thinking, and behavior. By boosting levels of the chemical messenger acetylcholine, Rivastigmine Tartrate can temporarily improve brain function in some Alzheimer's sufferers, though it does not halt the progress of the underlying disease. Rivastigmine Tartrate may become less effective as the disease progresses.

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Rivastigmine Tartrate

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