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Rivastigmine tartrate

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HOME >> API >> API List 3 >> Rivastigmine Tartrate >> Interaction

Rivastigmine Tartrate CAS Registry Number 129101-54-8

INTERACTION
Rivastigmine Tartrate
CAS Registry Number 129101-54-8

Effect of Rivastigmine Tartrate on the Metabolism of Other Drugs: Rivastigmine is primarily metabolized through hydrolysis by esterases. Minimal metabolism occurs via the major cytochrome P450 isoenzymes.

Effect of Other Drugs on the Metabolism of Rivastigmine Tartrate: Drugs that induce or inhibit CYP450 metabolism are not expected to alter the metabolism of rivastigmine. Single dose pharmacokinetic studies demonstrated that the metabolism of rivastigmine is not significantly affected by concurrent administration of digoxin, warfarin, diazepam, or fluoxetine.

Population PK analysis with a database of 625 patients showed that the pharmacokinetics of rivastigmine were not influenced by commonly prescribed medications such as antacids, antihypertensives, β-blockers, calcium channel blockers, antidiabetics , nonsteroidal antiinflammatory drugs , estrogens , salicylate analgesics , antianginals , and antihistamines

Use with Anticholinergics: Because of their mechanism of action, cholinesterase inhibitors have the potential to interfere with the activity of anticholinergic medications.

Use with Cholinomimetics and Other Cholinesterase Inhibitors: A synergistic effect may be expected when cholinesterase inhibitors are given concurrently with succinylcholine, similar neuromuscular blocking agents or cholinergic agonists such as bethanechol.

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Rivastigmine Tartrate

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