Topiramate Drugs, Importers, Informations, User, warnings, Reviews, Side, Effects, Symptoms, Molecular Formula C12H21NO8S, Molecular Weight 339.36,

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HOME >> API >> API List 3 >> Topiramate >> Interaction

INTERACTION
Topiramate CAS Registry Number 97240-79-4

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

The amount of topiramate in the blood may be decreased by the following medicines:

* carbamazepine

* phenobarbital

* phenytoin

* primidone.

Topiramate may increase the blood level of phenytoin, and people taking this combination of antiepileptic medicines should have the amount of phenytoin in their blood monitored.

It is recommended that people who are taking any antiepileptic medicines should avoid taking the herbal remedy St John's wort (Hypericum perforatum). This is because St John's wort may affect the level of antiepileptic medicines in the blood and could increase the risk of seizures.

Topiramate may make combined oral contraceptive pills less effective by reducing the blood level of oestrogen. For this reason, women using combined oral contraceptives should be prescribed a pill(s) containing at least 50 micrograms of oestrogen. Alternatively, non-hormonal methods of contraception such as condoms should be used to prevent pregnancy. If you are taking an oral contraceptive with topiramate you should tell your doctor if you experience any changes in your menstrual bleeding, because this may mean that your pill is becoming less effective at preventing pregnancy.

There may be an increased risk of drowsiness and sedation if this medicine is taken with any of the following (which can also cause drowsiness):

* alcohol

* barbiturates, eg phenobarbital

* benzodiazepines, eg diazepam

* sedating antihistamines, eg chlorphenamine

* sleeping tablets

* strong opioid painkillers, eg morphine, codeine

* tricyclic antidepressants, eg amitriptyline.

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