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HOME >> API >> API List 3 >> Topiramate >> Precautions

PRECAUTIONS
Topiramate CAS Registry Number 97240-79-4

Before taking topiramate,

* tell your doctor and pharmacist if you are allergic to topiramate or any other medications.
* tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetazolamide (Diamox); amitriptyline; antidepressants; antihistamines; dichlorphenamide ; digoxin ; ipratropium ; iron; isoniazid  hydrochlorothiazide ; lithium ; medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, ulcers, or urinary problems; metformin ; methazolamide; oral contraceptives (birth control pills); other medications for seizures such as carbamazepine  and phenytoin ; pioglitazone ; risperidone ; salicylate pain relievers such as aspirin, choline magnesium trisalicylate , choline salicylate , diflunisal , magnesium salicylate , and salsalate ; sedatives; sleeping pills; tranquilizers; valproic acid ; and zonisamide . Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
* tell your doctor if you or any family members have or have ever had kidney stones, if you drink or have ever drunk large amounts of alcohol, and if you have ever thought about killing yourself or tried to do so. Also tell you doctor if you have or have ever had metabolic acidosis (a disturbance in the body's acid-base balance that results in excessive acidity of the blood); osteopenia, osteomalacia, or osteoporosis (conditions in which the bones are soft or brittle and may break easily); diabetes; glaucoma (a type of eye disease); any disease that affects your breathing such as asthma or chronic obstructive pulmonary disease (COPD); depression or abnormal moods; a growth problem; or liver or kidney disease. Also tell your doctor if you have diarrhea or if you develop diarrhea during your treatment.
* tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking topiramate, call your doctor.
* if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking topiramate.
* you should know that topiramate may make you drowsy, dizzy, confused, or unable to concentrate. Do not drive a car or operate machinery until you know how this medication affects you.
* if you are taking topiramate to control seizures, you should know that you may continue to have seizures during your treatment. You may need to avoid activities such as swimming, driving, and climbing so that you will not harm yourself or others if you lose consciousness during a seizure.
* ask your doctor about the safe use of alcoholic beverages while you are taking topiramate.
* if you are taking oral contraceptives (birth control pills), tell your doctor if unexpected bleeding or spotting occurs. Topiramate can decrease the effectiveness of oral contraceptives.
* you should know that topiramate can prevent you from sweating and make it harder for your body to cool down when it gets very hot. This happens most often in warm weather and to children who take topiramate. Avoid exposure to heat, drink plenty of fluids and tell your doctor if you have a fever, headache, muscle cramps, or an upset stomach, or if you are not sweating as usual.
* you should know that you may be more likely to develop a kidney stone while you are taking topiramate. Drink 6 to 8 glasses of water every day to prevent kidney stones from forming.

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