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HOME >> API >> API List 3 >> Tramadol HCl >> Side Effects

SIDE EFFECTS
Tramadol Hcl CAS Registry Number 22204-88-2

Side effects reported with Tramadol Hcl include constipation, somnolence (sleepiness) and increased sweating.

Tramadol Hcl should not be used concomitantly with alcohol. Since tramadol can reinitiate physical dependence, Tramadol Hcl is not recommended for subjects disposed to drug or alcohol abuse.

Seizures have been reported in subjects receiving tramadol treatment. Data indicates that the risk of seizures is increased with doses of tramadol above the recommended range. Tramadol use has been shown to increase seizure risk in subjects taking the following medications:

* Selective serotonin reuptake inhibitors
* Tricyclic antidepressants
* Opioids

Additionally, tramadol may enhance the risk of seizures in subjects taking the following:

* MAO inhibitors
* Neuroleptics
* Other drugs that reduce the seizure threshold

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