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Dextromethorphan Hydrobromide
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Chemical Formulas
Dextromethorphan Hydrobromide
C18H25NO·HBr·H2O 370.32
Synonym:
Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-, hydrobromide,
monohydrate.
3-Methoxy-17-methyl-9α,13α,14α- morphinan hydrobromide,
monohydrate
Identifiers
Cas No : 6700-34-1
ATC code R05DA09
PubChem CID 15978238
DrugBank APRD00655
ChemSpider 13109865 Yes
UNII 7355X3ROTS Yes
Chemical data
Formula C18H25NO
Mol. mass 271.4 g/mol
SMILES eMolecules & PubChem
InChI
Physical data
Melt. point 111 °C (232 °F)
Pharmacokinetic data
Bioavailability 11%
Molecular Weight: 352.31
Empirical Formula (Hill Notation): C18H25NO · HBr · H2O
Properties
Suitability meets USP testing specifications
Storage Temperature
Room temperature
Product
Information
This product meets USP specifications (Current through USP 23, 4th
Supplement), and is traceable to USP Reference Standard lot I
Preserve in tight containers at room temperature. Do not dry;
determine water content titrimetrically at time of use. Use
promptly. Discard unused material.
|
TEST |
USP
23 SPECIFICATIONS |
Result |
Infrared
absorption spectrum
(197K) |
compares
to standard |
conforms
to USP RS lot I |
Ultraviolet
absorption spectrum
100 μg/mL (197U) |
absorptivities at 278 nm,
calculated on the anhydrous basis, differ by not more
than 3% |
conforms to USP RS lot I |
| Identification
C |
when
dissolved 1 in 200, acidified with nitric acid, the addition of
silver nitrate causes a yellowish white precipitate to form. |
passes |
| Specific
rotation, [α]325 180 mg/10 ml solution in dioxane (781) |
specific rotation at 325 nm, calculated on the anhydrous basis,
does not differ from standard by more than 1.0% |
passes |
| pH 1
in 100 solution (791) |
between 5.2 and 6.5 |
6.5 |
| Water,
Method I (921) |
between 3.5% and 5.5% |
4.8% |
| Residue
on ignition (281) |
not
more than 0.1% |
passes |
| Limit
of N,N-dimethylaniline |
0.001% |
passes |
| Phenolic
compounds |
no
blue-green color develops |
passes |
Assay
- high pressure liquid
chromatography (621) |
not
less than 98.0% and
not more than 102.0% |
101.8% |
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*** SAMPLE AVAILABLE
Information
Associated with Product :
Dosage
Uses
Side Effects
Pharmacology
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 Note:
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to the manufacture of the substances. For any (Control Substance) products
Import and Export *** subjected to your country government laws /control
substance ACT.
Note /Government Notification:
These chemicals are designated as those that are used in the manufacture of
the controlled substances and are important to the manufacture of the
substances. For any (Control Substance) products Import and Export ***
subjected to your country government laws /control substance ACT.
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