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Buspirone base
Molecular Formula C21H31N5O2
Molecular Weight 385.51
CAS Registry Number 36505-84-7
Bioavailability low and variable (approx. 5%), due to high first pass
metabolism
Protein binding 95% bound to plasma proteins
Metabolism mainly hepatic, active metabolite 1-Pyrimidylpiperazin (1-PP)
Half life 2-3hr
Excretion urine (29-63%) and feces (18-38%) in the form of metabolites

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