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Dexamethasone

HOME >> API >> Dexamethasone

Dexamethasone

Systematic (IUPAC) name
(8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17- odecahydro-3H-cyclopenta[a]phenanthren-3-one

Identifiers
CAS number 50-02-2
ATC code A01AC02 C05AA09, D07AB19, H02AB02, R01AD03, S01BA01, S02BA06, S03BA01
PubChem CID 5743
DrugBank APRD00674
ChemSpider 5541
UNII 7S5I7G3JQL

Dexamethasone Formula

Chemical data
Formula C22H29FO5
Mol. mass 392.461 g/mol
SMILES eMolecules & PubChem

Pharmacokinetic data
Bioavailability 80-90%
Protein binding 70%
Metabolism hepatic
Half-life 36-54 hours
Excretion renal

Therapeutic considerations
Pregnancy cat. C(US)
Legal status Prescription only
Routes Oral, IV, IM, SC and IO

(dexamethasone tablets, USP) tablets, for oral administration, are supplied in two potencies, 0.5 mg and 0.75 mg. Inactive ingredients are calcium phosphate, lactose, magnesium stearate, and starch. Tablets 0.5 mg also contain D&C Yellow 10 and FD&C Yellow 6. Tablets 0.75 mg also contain FD&C Blue 1.

The molecular weight for dexamethasone is 392.47. It is designated chemically as 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione. The empirical formula is C22H29FO5 and the structural formula is:

dexamethasone structural formula illustration

Dexamethasone, a synthetic adrenocortical steroid, is a white to practically white, odorless, crystalline powder. It is stable in air. It is practically insoluble in water.

Standard I.P./B.P./U.S.P.
Storage Store in a well closed light resistant container in cool and dry place.

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