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HOME >> Pharmaceuticals API List 1 >> Pharmaceuticals API List 2 >> Losartan Potassium >> Interaction

Losartan Potassium CAS Registry Number 124750-99-8

INTERACTION
Losartan Potassium CAS Registry Number 124750-99-8

If Losartan Potassium  is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before taking Losartan Potassium  with the following:

Diuretics that leave potassium in the body, such as amiloride, spironolactone, and triamterene
Indomethacin
Ketoconazole
Troleandomycin

Fluconazole

Losartan plasma levels may be elevated, increasing the antihypertensive and adverse effects.
Grapefruit juice

Rate and magnitude of losartan metabolism to its active metabolite may be decreased, possibly reducing the efficacy; however, based on available data, a clinically important interaction is unlikely.
Indomethacin

The antihypertensive effect of losartan may be blunted.
Lithium

Plasma concentrations may be increased by losartan, resulting in an increase in the pharmacologic and adverse effects of lithium.
Potassium supplement

Concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.
RifamycinsLosartan plasma levels may be reduced, decreasing the antihypertensive effects.

Information Associated with Product:
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Losartan Potassium

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