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Oxethazaine taj Pharmaceuticals Ltd.

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HOME >> API >> API List 3 >> Oxethazaine >> Precautions

Oxethazaine CAS Registry Number 126-27-2

Oxethazaine CAS Registry Number 126-27-2

The use of magnesium-containing antacids in patients with mild to moderate renal impairment should be carefully monitored due to a possible increased danger of hypermagnesaemia.
In patients with chronic renal failure, hyperaluminaemia may occur. Encephalopathy and dementia may occur in patients with poor renal function or patients on dialysis, due to an increase in plasma concentration of aluminium.
Hypophosphataemia may occur with prolonged administration or large doses of aluminium-containing antacids (except aluminium phosphate) especially in patients with an inadequate dietary intake of phosphorus.
Laboratory Tests –Serum phosphate levels should be monitored at monthly or bi-monthly intervals in patients on maintenance haemodialysis who are receiving chronic antacid therapy.
Use in children –The safety and effectiveness of Oxethazaine  in children has not been established.
Drug Interactions –The rate and/or extent of absorption of many medicines may be increased or decreased. Therefore, medication should not be taken within one to two hours of Oxethazaine .
An incomplete list of substances for which the above statement has been shown to apply includes: tetracycline, iron salts, isoniazid, ethambutol, some anti-muscarinic drugs, benzodiazepines, phenothiazines ranitidine, indomethacin, phenytoin, nitrofurantoin, Vitamin A, fluoride and phosphate. An increase in the plasma level of quinidine and possible toxicity may result it alkalisation of the urine occurs following antacid therapy.

Pregnancy: A reproduction study performed in rabbits revealed no evidence of harm to the fetus. There are, however, no adequate or well-controlled studies in pregnant women. Use during pregnancy if the benefits outweigh the potential risks.

Lactation: It is not known if Oxethazaine  is excreted in breast milk. Because many drugs are excreted in breast milk, a decision should be made whether to discontinue nursing or to discontinue Oxethazaine , taking into account the importance of the drug to the mother and the potential risk to the infant.

Children: The safety and effectiveness of Oxethazaine  in children have not been established. Therefore this product is recommended for adult use only.

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