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CAS Number 109552-15-0
USES: This medication is used to treat high blood calcium levels (hypercalcemia)
that may occur with cancer. Pamidronate is also used to treat a certain type
of bone disease (Paget's disease) and bone problems that may occur with
certain cancers (breast cancer, multiple myeloma). Pamidronate belongs to a
class of drugs known as bisphosphonates. It works by reducing the amount of
calcium released from your bones into your blood.
HOW TO USE: Follow all instructions for proper mixing and dilution
with the correct IV fluids. Before using, check this product visually for
particles or discoloration. If either is present, do not use the liquid. Do
not mix this drug with solutions that contain calcium (e.g., lactated
Ringer's solution). If you have questions regarding the use of this
medication, consult your pharmacist. The dosage is based on your medical
condition and response to therapy. The dose should not be greater than 90
milligrams or be given over less than 2 hours. Doses that are higher than 90
milligrams, doses given too quickly, or previous use of this medication
increase the risk for kidney problems. For high calcium levels, one dose is
usually given. If needed, a repeat dose may be given after 7 days.For
Paget's disease, this drug is usually given once a day for 3 days or as
directed by your doctor. For bone problems, use as directed by your doctor.
SIDE EFFECTS: Mild fever, redness/swelling/pain at the injection
site, stomach pain, loss of appetite, dizziness, headache, nausea, vomiting,
or constipation may occur. If any of these effects persist or worsen, tell
your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she
has judged that the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, seek
immediate medical attention if you notice any symptoms of a serious allergic
reaction, including: rash, itching, swelling, severe dizziness, trouble
PRECAUTIONS: Before using this medication, tell your doctor or
pharmacist your medical history, especially of: kidney disease, asthma,
severe loss of body water (dehydration), thyroid surgery. This drug may make
you dizzy or lightheaded. Use caution while driving, using machinery, or
doing any other activity that requires alertness. Limit alcoholic beverages.
MISSED DOSE: It is important to receive each dose as scheduled. If
you miss a dose, contact your doctor for a new schedule.
STORAGE: Store the unmixed vials at room temperature between 56-86
degrees F (13-30 degrees C) away from light and moisture. This medication
must be diluted with IV fluids just before use. However, the mixed vial can
be refrigerated at 36-46 degrees F (2-8 degrees C) for 24 hours. Discard the
mixed vial after 24 hours. Discard any unused portion of the vial. Keep all
medicines away from children
Do not flush medications down the toilet or pour them into a drain unless
instructed to do so. Properly discard this product when it is expired or no