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HOME >> Pharmaceuticals API List 2 >> Primidone >> Consumer Information

Primidone CAS number 125-33-7

Primidone CAS number 125-33-7


Primidone  is used to treat epileptic and other seizures. It can be used alone or with other anticonvulsant drugs. It is chemically similar to barbiturates.
How should you take Primidone?

Take Primidone  exactly as prescribed. Do not change from one manufacturer's product to another without consulting your doctor.

Side Effects

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Primidone .

* Side effects may include:
Lack of muscle coordination, vertigo or severe dizziness

Special warnings about Primidone

Remember that you must not stop taking Primidone  suddenly.

It can take several weeks for the full effectiveness of Primidone  to be seen.

Since Primidone  is generally given for long periods of time, your doctor will check your blood count every 6 months.
Recommended dosage for Primidone


For people 8 years of age and older who have not been treated before, the doctor will start Primidone  as follows, using either 50-milligram or scored 250-milligram Primidone  tablets:

Days 1 to 3: 100 to 125 milligrams at bedtime

Days 4 to 6: 100 to 125 milligrams 2 times a day

Days 7 to 9: 100 to 125 milligrams 3 times a day

Day 10 to maintenance: 250 milligrams 3 times a day

For most adults and children 8 years of age and over, the usual maintenance dosage is 250 milligrams 3 or 4 times a day. If you need more, your doctor may increase the dose to five or six 250-milligram tablets. You should not take more than 500 milligrams 4 times a day (2000 milligrams or 2 grams).

In patients already receiving other anticonvulsants, the usual starting dose of Primidone  is 100 to 125 milligrams at bedtime; your doctor will gradually increase this dose to a maintenance level as the other drug is gradually decreased. Your doctor will either find a working level for the combination or withdraw the other medication completely. When Primidone  is to be used as a single drug, it will take at least 2 weeks to make the transition from two drugs to one.


Days 1 to 3: 50 milligrams at bedtime

Days 4 to 6: 50 milligrams 2 times a day

Days 7 to 9: 100 milligrams 2 times a day

Day 10 to maintenance: 125 milligrams 3 times a day to 250 milligrams 3 times day

The usual maintenance dosage is 125 to 250 milligrams 3 times daily or 10 to 25 milligrams per 2.2 pounds of body weight per day, divided into smaller doses.

Over dosage

Any medication taken in excess can have serious consequences. If you suspect a Primidone  overdose, seek medical attention immediately.

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