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CAS Registry Number 165800-06-6
Before receiving zoledronic acid injection,
* tell your doctor and pharmacist if you are allergic to zoledronic acid or
any other medications.
* tell your doctor and pharmacist what prescription and nonprescription
medications, vitamins, nutritional supplements, and herbal products you are
taking or plan to take. Be sure to mention any of the following:
aminoglycoside antibiotics such as amikacin , gentamicin , kanamycin ,
neomycin , paromomycin , streptomycin, and tobramycin ; cancer chemotherapy
medications; loop diuretics ('water pills') such as bumetanide , ethacrynic
acid , and furosemide ; oral steroids such as dexamethasone
methylprednisolone , and prednisone and thalidomide . Many other
medications may interact with zoledronic acid, so tell your doctor about all
the medications you are taking, even those that do not appear on this list.
Your doctor may need to change the doses of your medications or monitor you
carefully for side effects.
* tell your doctor if you have ever had a low level of calcium in your
blood. Your doctor will probably check the level of calcium in your blood
before you begin treatment and may not prescribe this medication if the
level is too low.
* tell your doctor if you have been treated with zoledronic acid or other
bisphosphonates in the past; if you have ever had surgery on your
parathyroid gland (small gland in the neck) or thyroid gland or surgery to
remove sections of your small intestine; and if you have or have ever had
heart failure (condition in which the heart cannot pump enough blood to
other parts of the body); anemia (condition in which red blood cells cannot
bring enough oxygen to other parts of the body); any condition that stops
your blood from clotting normally; any condition that prevents your body
from absorbing nutrients from food or problems with your mouth, teeth, or
gums; an infection, especially in your mouth; asthma, especially if it is
made worse by aspirin; or parathyroid, kidney, or liver disease.
* tell your doctor if you are pregnant, plan to become pregnant, or are
breast-feeding. You should use a reliable method of birth control to prevent
pregnancy while you are receiving zoledronic acid. If you become pregnant
while receiving zoledronic acid, call your doctor. Talk to your doctor if
you plan to become pregnant at any time in the future because zoledronic
acid may remain in your body for years after you stop receiving it.
* you should know that zoledronic acid injection may cause severe bone,
muscle, or joint pain. You may begin to feel this pain within days, months,
or years after you first receive zoledronic acid injection. Although this
type of pain may begin after you have received zoledronic acid injection for
some time, it is important for you and your doctor to realize that it may be
caused by zoledronic acid. Call your doctor right away if you experience
severe pain at any time during your treatment with zoledronic acid inejction.
Your doctor may stop giving you zoledronic acid injection and your pain may
go away after you stop treatment with this medication.
* you should know that zoledronic acid may cause serious problems with your
jaws, especially if you have dental surgery or treatment while you are using
the medication.A dentist should examine your teeth and perform any needed
treatments before you start to use zoledronic acid. Be sure to brush your
teeth and clean your mouth properly while you are using zoledronic acid.
Talk to your doctor before having any dental treatments while you are using