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HOME >> API >> API List1 >> Acamprosate Calcium >> Mechanism Of Action

PI-21684 Acamprosate calcium (77337-73-6)

Mechanism Of Action
Both COX-1 and COX-2 catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. Valdecoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, important for the mediation of inflammation and pain. Unlike non-selective NSAIDs, Valdecoxib does not inhibit platelet aggregation.

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