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HOME >> API >> API List 4 >> Buprenorphine HCl >> Dosage

DOSAGE
Buprenorphine HCl CAS No: [53152-21-9]

Tablets
Adults

SL (Use limited to health care providers who meet certain qualifications and have notified the Health and Human Services of their intent to prescribe.) 12 to 16 mg/day.
Injection
Adults and children (13 yr of age and older)

IM/IV 0.3 mg deep IM or slow IV (over at least 2 min) at up to 6 h intervals, as needed. May repeat once (up to 0.3 mg) 30 to 60 min after initial dosage, if required.
General Advice

Tablets
For SL use only. Do not chew, crush, or swallow tablets. Place tablets under the tongue until they are dissolved. Swallowing tablets reduces effectiveness.

Buprenorphine and buprenorphine tablets are interchangeable.

Do not initiate therapy until objective signs of opioid withdrawal are evident.

For dose requiring more than 2 tablets, place all tablets under the tongue and allow to dissolve. If patient cannot fit more than 2 tablets under the tongue at one time, then place 2 tablets under the tongue at a time.

Injection
For deep IM or slow IV (over at least 2 min) administration only. Not for intradermal, SC, or intra-arterial administration.

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