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HOME >> API >> API List 4 >> Buprenorphine HCl >> Precautions

Buprenorphine HCl CAS No: [53152-21-9]

PRECAUTIONS
Buprenorphine HCl CAS No: [53152-21-9]

Ensure that liver enzymes and hepatic function are evaluated prior to starting therapy and periodically during treatment. Document type of opioid dependence (eg, long-, short-acting), time since last opioid use, and degree of opioid dependence prior to starting SL tablets. Monitor patient for respiratory depression. If noted, re-establish adequate ventilation with mechanical assistance and notify health care provider immediately. Buprenorphine  may not be effective in reversing respiratory depression caused by this drug. Monitor patient for narcotic withdrawal symptoms, CNS, GI, and general body side effects.
Children

Safety and efficacy not established in children under 13 yr of age.
Special Risk Patients

Use with caution in elderly or debilitated patients; use with caution in patients with impaired hepatic, renal or pulmonary function, myxedema or hypothyroidism, adrenal cortical insufficiency (eg, Addison disease), CNS depression or coma, toxic psychoses, prostatic hypertrophy or urethral stricture, acute alcoholism, delirium tremens or kyphoscoliosis, biliary tract dysfunction.
Head injury or increased intracranial pressure

Use with caution; drug can increase CSF pressure.
Narcotic dependent patients

Use in physically dependent individuals may result in withdrawal effects.

Information Associated with Product:
DRUG DESCRIPTION
DOSAGE
SIDE EFFECTS
PRECAUTIONS >>
INTERACTION
CONSUMER INFORMATION
 
 
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