CAS Registry Number 107133-36-8
Perindopril erbumine is a white, crystalline powder with a molecular weight
of 368.47 (free acid) or 441.61 (salt form). It is freely soluble in water
(60% w/w), alcohol and chloroform.
Perindopril is the free acid form of perindopril erbumine, is a pro-drug and
metabolized in vivo by hydrolysis of the ester group to form perindoprilat,
the biologically active metabolite.
Perindopril Tablets is available in 2 mg, 4 mg and 8 mg strengths for
oral administration. In addition to perindopril erbumine, each tablet
contains the following inactive ingredients: colloidal silica (hydrophobic),
lactose, magnesium stearate and microcrystalline cellulose. The 4 and 8 mg
tablets also contain iron oxide.
Perindopril is used alone or in combination with other medications to treat
high blood pressure. Perindopril is in a class of medications called
angiotensin-converting enzyme (ACE) inhibitors. It makes blood flow more
smoothly by preventing the production of certain natural chemicals that
tighten the blood vessels.
Essential hypertension. Stable coronary artery disease: reduction of risk of
cardiac events in patients with a history of myocardial infarction and/or
revascularization. Treatment of symptomatic heart failure.