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Perindopril

PRECAUTIONS

Perindopril CAS Registry Number 107133-36-8


Assess renal function before and during treatment where appropriate. Renovascular hypertension. Surgery/anaesthesia. Renal failure: the dose should be cautiously adjusted in accordance with the creatinine clearance (refer to complete data sheet). Symptomatic hypotension is rarely seen, but is more likely in volume-depleted patients, those receiving diuretics, or with the first two doses. In diuretic-treated patients, stop the diuretic 3 days before starting Coversyl (perindopril). A diuretic may later be given in combination if necessary; potassium-sparing diuretics are not recommended. Combination with neuroleptics or imipramine-type drugs may increase the hypotensive effect. Serum lithium concentrations may rise during lithium therapy.

 

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