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CAS Registry Number 165800-06-6
This medication is used to treat high blood calcium levels (hypercalcemia)
that may occur with cancer. Zoledronic acid is also used to treat bone
problems that may occur with a certain type of cancer (multiple myeloma) and
other types of cancer. Zoledronic acid belongs to a class of drugs known as
bisphosphonates. It works by reducing the amount of calcium released from
your bones into your blood.
Nausea, stomach pain, vomiting, dizziness, diarrhea, flu-like symptoms
(e.g., fever, chills, muscle/joint aches), or pain/redness/swelling at the
injection site may occur. If any of these effects persist or worsen, tell
your doctor or pharmacist promptly.
Tell your doctor immediately if any of these unlikely but serious side
effects occur: increased or severe bone/joint/muscle pain, jaw pain, unusual
weakness, unusual tiredness, trouble sleeping, trouble swallowing, eye
problems (e.g., "pinkeye"/conjunctivitis), vision problems (e.g., trouble
seeing), swelling legs, numb/tingling skin, fast/pounding/irregular
heartbeat, persistent sore throat with fever, unusual bruising/bleeding,
change in the amount of urine, burning/painful urination, mental/mood
changes (e.g., agitation, anxiety, confusion).
Before using zoledronic acid, tell your doctor or pharmacist if you are
allergic to it; or to other bisphosphonates such as alendronate, risedronate;
or if you have any other allergies.
Before using this medication, tell your doctor or pharmacist your medical
history, especially of: kidney problems, asthma, severe loss of body water
Infrequently, serious jawbone problems (osteonecrosis) have occurred in
people using this medication. Most people were also using other medications
or had conditions that might have caused the jawbone problem. If you have
cancer, anemia, blood clotting disorders, infections/other diseases of the
mouth, or poor dental hygiene, see your dentist for a full
examination/treatment before you start zoledronic acid. Tell your dentist
that you will be using zoledronic acid, and make sure he or she knows of all
your medications, especially corticosteroids (e.g., prednisone) and cancer
chemotherapy. Also tell him or her of your entire medical history,
especially of any cancer radiation treatments.
It is important to receive each dose as scheduled. If you miss a dose,
contact your doctor for a new schedule.
Store the unmixed vials at room temperature between 56-86 degrees F (13-30
degrees C) away from light and moisture. After mixing with IV fluids, this
product should be refrigerated between 36-46 degrees F (2-8 degrees C) and
used within 24 hours. Discard the mixed drug after 24 hours. Discard any
unused portion of the vial. Keep all medicines away from children and pets.