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HOME >> API >> API List 3 >> Zoledronic Acid >> Precautions

PRECAUTIONS
Zoledronic Acid CAS Registry Number 165800-06-6

Before receiving zoledronic acid injection,

* tell your doctor and pharmacist if you are allergic to zoledronic acid or any other medications.
* tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin , gentamicin , kanamycin , neomycin , paromomycin , streptomycin, and tobramycin ; cancer chemotherapy medications; loop diuretics ('water pills') such as bumetanide , ethacrynic acid , and furosemide ; oral steroids such as dexamethasone  methylprednisolone , and prednisone  and thalidomide . Many other medications may interact with zoledronic acid, so tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
* tell your doctor if you have ever had a low level of calcium in your blood. Your doctor will probably check the level of calcium in your blood before you begin treatment and may not prescribe this medication if the level is too low.
* tell your doctor if you have been treated with zoledronic acid or other bisphosphonates in the past; if you have ever had surgery on your parathyroid gland (small gland in the neck) or thyroid gland or surgery to remove sections of your small intestine; and if you have or have ever had heart failure (condition in which the heart cannot pump enough blood to other parts of the body); anemia (condition in which red blood cells cannot bring enough oxygen to other parts of the body); any condition that stops your blood from clotting normally; any condition that prevents your body from absorbing nutrients from food or problems with your mouth, teeth, or gums; an infection, especially in your mouth; asthma, especially if it is made worse by aspirin; or parathyroid, kidney, or liver disease.
* tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should use a reliable method of birth control to prevent pregnancy while you are receiving zoledronic acid. If you become pregnant while receiving zoledronic acid, call your doctor. Talk to your doctor if you plan to become pregnant at any time in the future because zoledronic acid may remain in your body for years after you stop receiving it.
* you should know that zoledronic acid injection may cause severe bone, muscle, or joint pain. You may begin to feel this pain within days, months, or years after you first receive zoledronic acid injection. Although this type of pain may begin after you have received zoledronic acid injection for some time, it is important for you and your doctor to realize that it may be caused by zoledronic acid. Call your doctor right away if you experience severe pain at any time during your treatment with zoledronic acid inejction. Your doctor may stop giving you zoledronic acid injection and your pain may go away after you stop treatment with this medication.
* you should know that zoledronic acid may cause serious problems with your jaws, especially if you have dental surgery or treatment while you are using the medication.A dentist should examine your teeth and perform any needed treatments before you start to use zoledronic acid. Be sure to brush your teeth and clean your mouth properly while you are using zoledronic acid. Talk to your doctor before having any dental treatments while you are using this medication.

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DRUG DESCRIPTION DOSAGE SIDE EFFECTS PRECAUTIONS >> INTERACTION CONSUMER INFORMATION
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