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HOME >> API >> API List 3 >> Zoledronic Acid >> Dosage

DOSAGE
Zoledronic Acid CAS Registry Number 165800-06-6

Follow all instructions for proper mixing and dilution with the correct IV fluids. Do not mix this drug with calcium-containing mixing solutions (e.g., Lactated Ringers). If you have questions regarding the use of this medication, consult your pharmacist. Give this medication by vein (IV) over at least 15 minutes in a saline (0.9% sodium chloride) or dextrose (D5W) solution as directed by your doctor. Additional IV fluids may be given before, during, or after your treatment with this drug. The dosage is based on your medical condition and response to therapy but should not be greater than 4 mg (each dose) or be given faster than the recommended rate (over 15 minutes). Doses greater than 4 mg or given quickly increase the risk for kidney problems. Consult your doctor or pharmacist. It may take up to 7 days before the full benefit of this drug takes effect. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard needles and medical supplies safely.

Zoledronic acid comes as a solution (liquid) to inject into a vein over at least 15 minutes. It is usually injected by a health care provider in a doctor's office, hospital, or clinic. When zoledronic acid injection is used to treat high blood levels of calcium caused by cancer it is usually given as a single dose. A second dose may be given at least 7 days after the first dose if blood calcium does not drop to normal levels or does not remain at normal levels. When zoledronic acid injection is used to treat bone damage caused by multiple myeloma or cancer that has spread to the bones, it is usually given once every 3-4 weeks. When zoledronic acid injection is used to treat osteoporosis, it is usually given once a year. When zoledronic acid is used to treat Paget's disease of bone, it is usually given as as a single dose, but additional doses may be given after some time has passed. You may experience a reaction during the first few days after you receive a dose of zoledronic acid injection. Symptoms of this reaction may include flu-like symptoms, fever, headache, and bone or muscle pain. These symptoms may begin during the first 3 days after you receive a dose of zoledronic acid injection and may last 3-14 days. Your doctor may recommend that you take a nonprescription pain reliever/fever reducer after you receive zoledronic acid injection to prevent or treat these symptoms.

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