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DOSAGE
Cas No. 111470-99-6.

Dosage must be individualized on the basis of both effectiveness and tolerance for each individual component in the treatment of hypertension/angina and hyperlipidemia.

The usual initial antihypertensive oral dose of amlodipine is 5 mg once daily with a maximum dose of 10 mg once daily. Small, fragile, or elderly individuals, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding amlodipine to other antihypertensive therapy.

Dosage should be adjusted according to each patient's need. In general, titration should proceed over 7 to 14 days so that the physician can fully assess the patient's response to each dose level. Titration may proceed more rapidly, however, if clinically warranted, provided the patient is assessed frequently.

The recommended dose of amlodipine for chronic stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. Most patients will require 10 mg for adequate effect. See ADVERSE REACTIONS section for information related to dosage and side effects.

Amlodpine Besylates may be substituted for its individually titrated components. Patients may be given the equivalent dose of Amlodpine Besylates or a dose of Amlodpine Besylates with increased amounts of amlodipine, atorvastatin or both for additional antianginal effects, blood pressure lowering, or lipid lowering effect.

How should you take Amlodipine besylate?

You should take Amlodipine besylate exactly as prescribed, even if your symptoms have disappeared. You will begin to see a drop in your blood pressure 24 hours after you start the medication.

• If you miss a dose...
  If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

• Storage instructions...
  Store at room temperature in a tightly closed container, away from light.
  
  Why is Amlodipine besylate prescribed?
  
  
  Norvasc is prescribed for angina, a condition characterized by episodes of crushing chest pain that usually results from a lack of oxygen in the heart muscle due to clogged arteries. Norvasc is also prescribed for high blood pressure. It is a type of medication called a calcium channel blocker. These drugs dilate blood vessels and slow the heart to reduce blood pressure and the pain of angina.

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