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INTERACTIONS
Cas No. 129722-12-9

Provigil and Aripiprazole Interactions

Coadministration with modafinil (the racemate) or armodafinil (the R-enantiomer) may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. Modafinil and armodafinil are modest inducers of CYP450 3A4, and pharmacokinetic studies suggest that their effects may be primarily intestinal rather than hepatic. Thus, clinically significant interactions would most likely be expected with drugs that have low oral bioavailability due to significant intestinal CYP450 3A4-mediated first-pass metabolism (e.g., buspirone, cyclosporine, lovastatin, midazolam, saquinavir, simvastatin, sirolimus, tacrolimus, triazolam,

Tell your physician if you have experienced any of these conditions:

• Suicidal thoughts or attempts
• Low blood volume or high blood pressure
• A family history of diabetes
• Have a history of seizures, dementia, Alzheimers disease
• Are taking any form of medication, herbal products or dietary supplements
• Suffer from depression or other mental and mood disorders
• Heart problems such as irregular heartbeat or heart failure
• Allergies to any ingredients in Aripiprazole Tablets, any medications, foods, dyes or preservatives
• Trouble swallowing or a history of neuroleptic malignant syndrome (NMS)
• Pregnant or trying to get pregnant
• Breastfeeding

If you are pregnant, breast feeding or currently trying to become pregnant, make sure your doctor is aware of your maternal condition; as Aripiprazole Tablets may not be recommended for certain situations.

What other drugs could interact with this medication?

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication.

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take.

Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.


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