Candesartan cilexetil Manufacturers in India Suppliers Candesartan cilexetil Exporters Distributors Candesartan cilexetil api active pharmaceuticals ingredients Candesartan cilexetil manufacturers Side Effects bulk drugs raw material Candesartan cilexetil companies Side Effects Importers Candesartan cilexetil Candesartan cilexetil Exporters Candesartan cilexetil exporters FDA Candesartan cilexetil DMF Symptoms Generic Taj Pharmaceuticals Ltd.

active pharmaceutical ingredients suppliers pharmaceutical Candesartan cilexetil manufacturing pharmaceutical drugs pharmaceutical intermediates Candesartan cilexetil pharmaceutical chemicals pharmaceutical raw materials Candesartan cilexetil active pharmaceutical ingredients Candesartan cilexetil committee active pharmaceutical ingredients manufacturer Candesartan cilexetil Active Pharmaceutical Ingredients manufacturer Candesartan cilexetil exporter drug ingredients pharmaceuticals

Pharmaceuticals API Manufacturer Candesartan cilexetil, Candesartan cilexetil manufacturer India, Candesartan cilexetil product, Candesartan cilexetil products, Api preparation, Certificate of Analysis API manufacturer product, Candesartan cilexetil anti ulcer product, Certificate of Origin COA Candesartan cilexetil COS Candesartan cilexetil, pharmaceutical generic, pharmaceutical drug, medical, Candesartan cilexetil pharma healthcare, pharma patents, contract MSDS manufacturing Trader Candesartan cilexetil pharma, generic pharma, HCL pharma MSDS pharmaceutical products, pharmaceutical formulations, generic import API, Candesartan cilexetil expectorant Pharmaceutical GMP Method of analysis formulations manufacturer, Candesartan cilexetil DMF drug master file pharmaceutical Anti Cancer active ingredient exporter from India, pharma Candesartan cilexetil ingredients, api, HIV Candesartan cilexetil, tablets, capsules, syrup & protein Candesartan cilexetil powder, GMP of Plant api nutraceuticals, gynec products, ortho ingredients in India, oncology products, Candesartan cilexetil gastroenterology products, buy, sell orthopaedic product, who gmp, cGMP, US FDA, Candesartan cilexetil WHO, UKMHRA Approval

PHARMALOGY
Candesartan cilexetil
145040-37-5  

Pharmacology

There is also an AT₂ receptor found in many tissues, but AT₂ is not known to be associated with cardiovascular homeostasis. Candesartan has much greater affinity ( > 10,000-fold) for the AT₁ receptor than for the AT₂ receptor.

Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE. Because candesartan does not inhibit ACE (kininase II), it does not affect the response to bradykinin. Whether this difference has clinical relevance is not yet known. Candesartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.

Pharmacokinetics

General

Candesartan cilexetil is rapidly and completely bioactivated by ester hydrolysis during absorption from the gastrointestinal tract to candesartan, a selective AT₁ subtype angiotensin II receptor antagonist. Candesartan is mainly excreted unchanged in urine and feces (via bile). It undergoes minor hepatic metabolism by O-deethylation to an inactive metabolite. The elimination half-life of candesartan is approximately 9 hours. After single and repeated administration, the pharmacokinetics of candesartan are linear for oral doses up to 32 mg of candesartan cilexetil. Candesartan and its inactive metabolite do not accumulate in serum upon repeated once-daily dosing.

Following administration of candesartan cilexetil, the absolute bioavailability of candesartan was estimated to be 15%. After tablet ingestion, the peak serum concentration (Cmax) is reached after 3 to 4 hours. Food with a high fat content does not affect the bioavailability of candesartan after candesartan cilexetil administration.

Information Associated with Product :  

Dosage
Uses
Side Effects
Pharmacology >>

                       
PDF DOWNLOAD      WORD DOCUMENT

Product Enquiry	Product Quotation	Sample Request	Place Your Order