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HOME >> API >> API List 2 >> Granisetron Hcl >> Drug Information

DRUG DESCRIPTION
Granisetron Hcl CAS Number 107007-99-8

Selective 5-HT 3 receptor antagonists. Serotonin receptors of the 5-HT 3 type are located peripherally on vagal nerve terminals, enteric neurons in the GI tract, and centrally in the chemoreceptor trigger zone. During chemotherapy, mucosal enterochromaffin cells from the small intestine release serotonin, which stimulates the 5-HT 3 receptors. This evokes vagal afferent discharge, inducing vomiting. Clearance is predominantly by hepatic metabolism, and plasma protein binding is approximately 65%.

Granisetron HCl falls within a class of small, very hydrophilic drug-molecules that cannot be delivered efficiently using existing passive transdermal delivery methods. Using Granisetron, TransPharma was able to demonstrate excellent results related to the three primary parameters: sustained release, constant blood drug levels and ease-of-use.

Granisetron HCl is an antiemetic drug, given for prevention of chemotherapy-induced nausea and for pre- and post-surgical nausea and vomiting. The drug is administered by intravenous (IV) injection, followed by oral administration. The IV administration is inconvenient, and oral dosing is often not effective in maintaining the desired constant drug levels in the bloodstream. A transdermal delivery of Granisetron can replace the IV and subsequent oral administration.

Granisetron HCl falls within a class of small, very hydrophilic drug-molecules that cannot be delivered efficiently using existing passive transdermal delivery methods. Using Granisetron, TransPharma was able to demonstrate excellent results related to the three primary parameters: sustained release, constant blood drug levels and ease-of-use.

Granisetron HCl is an antiemetic drug, given for prevention of chemotherapy-induced nausea and for pre- and post-surgical nausea and vomiting. The drug is administered by intravenous (IV) injection, followed by oral administration. The IV administration is inconvenient, and oral dosing is often not effective in maintaining the desired constant drug levels in the bloodstream. A transdermal delivery of Granisetron can replace the IV and subsequent oral administration.

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