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HOME >> API >> API List 2 >> Mesalazine >> Side Effects

SIDE EFFECTS
Mesalazine CAS Registry Number 89-57-6

Commonly:

* Diarrhea
* Nausea
* Cramping
* Flatulence [1]

Uncommonly:

* Headache
* Exacerbation of the colitis
* Hypersensitivity reactions (including rash, urticaria aka hives, interstitial nephritis and lupus erythematosus-like syndrome)
* Hair Loss
* Interstitial nephritis

Rarely:

* Acute pancreatitis,
* Hepatitis
* Nephrotic syndrome
* Blood disorders (including agranulocytosis, aplastic anaemia, leukopenia, neutropenia, thrombocytopenia)

Mesalazine avoids the sulphonamide side effects of Sulfasalazine (which contains additional (sulfapyridine), but carries additional rare risks of:

* Allergic lung reactions
* Allergic myocarditis
* Methaemoglobinaemia

Rarely:

* Acute pancreatitis,
* Hepatitis
* Nephrotic syndrome
* Blood disorders (including agranulocytosis, aplastic anaemia, leukopaenia, neutropaenia, thrombocytopaenia)

Mesalazine avoids the sulphonamide side effects of Sulfasalazine (which contains additional (sulfapyridine), but carries additional rare risks of:

* Allergic lung reactions
* Allergic myocarditis
* Methaemoglobinaemia

Monitoring

As a result of the small risks of kidney, liver and blood disorders, blood tests should be taken before and after starting treatment. Patients are advised to report any unexplained bleeding, bruising, purpura, sore throat, fever or malaise that occurs during treatment so that a full blood count can be urgently taken.

Information Associated with Product:

DRUG DESCRIPTION

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