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HOME >> API >> API List 3 >> Pentoxifylline >> Precautions

PRECAUTIONS
Pentoxifylline CAS NO 6493-05-6

Tell your doctor your complete medical history before you take any medicine. This medication should be used during pregnancy only if clearly needed. Because this medication appears in breast milk, consult your doctor before breast-feeding. It is best to avoid smoking because nicotine constricts blood vessels.

Patients with chronic occlusive arterial disease of the limbs frequently show other manifestations of arteriosclerotic disease. Pentoxifylline has been used safely for treatment of peripheral arterial disease in patients with concurrent coronary artery and cerebrovascular diseases, but there have been occasional reports of angina, hypotension, and arrhythmia. Controlled trials do not show that Pentoxifylline causes such adverse effects more often than placebo, but, as it is a methylxanthine derivative, it is possible some individuals will experience such responses. Patients on Warfarin should have more frequent monitoring of prothrombin times, while patients with other risk factors complicated by hemorrhage (e.g., recent surgery, peptic ulceration, cerebral and/or retinal bleeding) should have periodic examinations for bleeding including, hematocrit and/or hemoglobin.

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